Amoxicillin is an antibiotic with a broad spectrum of activity, utilized for the treatment of a range of bacterial infections. The dosage depends on the condition, severity, and patient’s age and weight.
1. Respiratory Tract Infections
A. Community-Acquired Pneumonia (CAP)
Adults: 1 g every 8 hours for 7–10 days.
Children: 45 mg/kg/day divided every 12 hours or 40 mg/kg/day divided every 8 hours for 7–10 days.
Adults: 500 mg every 8 hours or 875 mg every 12 hours for 5–7 days.
Children: 45–90 mg/kg/day in two doses for 10–14 days.
C. Strep Throat (Streptococcal Pharyngitis/Tonsillitis)
Adults: 500 mg every 12 hours or 1,000 mg once daily for 10 days.
Children: 50 mg/kg/day once daily or divided into two doses for 10 days.
2. Ear, Nose, and Throat Infections
A. Acute Otitis Media (Ear Infection)
Adults: 500 mg every 8 hours or 875 mg every 12 hours for 5–7 days.
Children: 80–90 mg/kg/day divided every 12 hours for 7–10 days.
B. Chronic Suppurative Otitis Media
Adults & Children: 500 mg every 8 hours for 14 days.
3. Urinary Tract Infections (UTIs)
Adults: 500 mg every 8 hours or 875 mg every 12 hours for 3–7 days.
Children: 40 mg/kg/day divided every 8–12 hours for 7 days.
Complicated UTI or Pyelonephritis
Adults: 1 g every 8 hours for 10–14 days.
4. Skin and Soft Tissue Infections
Adults & Children: 500 mg every 8 hours or 875 mg every 12 hours for 7–14 days.
5. Dental Infections (Abscess, Periodontitis)
Adults: 500 mg every 8 hours for 3–7 days.
Severe Infections:
Adults: 875 mg every 12 hours for 7–10 days.
6. Gastrointestinal Infections
A. Helicobacter pylori (H. pylori) Eradication
Triple Therapy (Adults Only):
Amoxicillin: 1 g every 12 hours
Clarithromycin: 500 mg every 12 hours
Proton Pump Inhibitor (PPI): e.g., Omeprazole 20 mg every 12 hours
Duration: 10–14 days.
7. Lyme Disease
Early Stage:
Adults: 500 mg every 8 hours for 14–21 days.
Children: 50 mg/kg/day divided every 8 hours for 14–21 days.
8. Endocarditis Prophylaxis (Before Dental Procedures in High-Risk Patients)
Adults: 2 g (single dose) 30–60 minutes before procedure.
Children: 50 mg/kg (single dose).
9. Bone and Joint Infections
Adults: 1 g every 8 hours for 6 weeks.
10. Typhoid Fever
Adults & Children: 75–100 mg/kg/day divided every 8 hours for 7–14 days.
Special Considerations
Renal Impairment: Reduce dose for GFR < 30 mL/min.
Pregnancy & Breastfeeding: Generally safe but consult a d
octor.
Missed Dose: Take as soon as possible, but do not double dose.
Always complete the full course of antibiotics as prescribed to prevent resistance.
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